DHM Side Effects (The Truth)

DHM Side Effects

DHM, or dihydromyricetin, has rapidly gained popularity for supporting liver health. As with newer science, many search for DHM side effects. As a supplement maker that uses a DHM-containing plant, we'll explore the truth behind DHM side effects and if DHM is safe.

What Is DHM?

DHM is a natural flavonoid derived from the Japanese Raisin tree (also know medicinally as hovenia dulcis). It has been used for hundreds of years in Traditional Chinese Medicine (TCM) for various purposes including alcohol consumption and detoxification.

Today, DHM (Dihydromyricetin) is primarily known for its potential to aid drinker via promoting liver health due to more modern studies that have come out the one Jing Liang did at UCLA finding " DHM anti-alcoholic effects." [⁴]

DHM supplements are the most commonly way to take the flavonoid — including DHM pills, DHM powders, and DHM tablets.


DHM Side Effects

Does DHM have side effects? In short yes it could, but let us explain.

Japanese Raisin tree has been shown to be safe without any side effects. However, DHM is a flavonoid derived from the plant, which doesn't have a long history of research when isolated.

When DHM is listed in products separate from Japanese Raisin, it's most commonly derived from a different plant that's called Vine Tea (ampelopsis grossedentata). This is an isolated form of DHM, rather than using it in its natural form from Japanese Raisin tree.

3 warnings with supplements using isolated DHM from Vine Tea:

1. Vine Tea Extracted

Vine Tea doesn't have nearly the same amount of research as Japanese Raisin. Furthermore, most supplement brands are promoting the benefits of Japanese Raisin while instead using DHM from Vine Tea. And some even hiding their DHM sources, this potentially could be misleading.

2. Made In China

DHM-related or DHM-concentrated raw materials are available only made in China. While some nutraceutical-grade ingredients come from China, regulations are a lot different than in the US and extra precautions should be taken.

3. Safety Concerns

It's been confirmed that any isolated or concentrated form of DHM can be chiral.³ For example, the artificial sweetener aspartame is known as a chiral molecule.² Due to being chiral material, DHM is not allowed by South Korea (KFDA) or even Canada because of consumer safety concern. It's not even considered GRAS in South Korea, generally recognized as safe.

    Overall, while DHM could have many benefits, there are clear concerns over the isolated form that isn't using the plant version of Japanese Raisin. Especially with South Korea and Canada not allowing concentrated DHM, DHM side effects can be a real problem and further research may need to be done.

    To avoid any potential DHM side effects, we recommend only using supplements utilizing Japanese Raisin extract with natural containing DHM, rather than companies promoting an isolated or concentrated version of DHM.

    Japanese Raisin Side Effects

    The plant that contains the DHM flavonoid, Japanese Raisin (hovenia dulcis), has been shown to be safe. A study with 14 days of observation concluded it to be safe with no toxic side effects.⁶

    By utilizing Japanese Raisin supplements, you can get DHM naturally in a whole-food format that shows to be safe and has long term use in Asia.

    Is DHM Safe?

    Due to our three warnings of using isolated or concentrated DHM from Vine Tea, we do not believe DHM is 100% safe.

    That being said, if using a natural extract of Japanese Raisin containing the DHM flavonoid, plenty of science backs this up as safe. We commended consuming Japanese Raisin formulated supplements, and researching the brand on their source of DHM.

    What's Missing In DHM?

    Research that we're exposed to has shown Japanese Raisin actually contains four (4) major flavonoids, DHM is only one of them. While DHM has become the most popular flavonoid, it's part of a much larger structure of components in Japanese Raisin that are beneficial.

    Hence, vast amounts of research and historical use of Japanese Raisin proves it to be the superior plant and supplement.

    What is DHM (Dihydromyricetin) Good For?

    DHM has become a cherished flavonoid from research showing its many benefits, combined with it confirmed as one of the major remedial components of Japanese Raisin.

    From high altitude performance to promoting liver health, consumers like supplementing DHM for many reasons.

    7 Things DHM Is Good For:

    1. Support Liver Health ⁷

    2. Lower Oxidative Stress ⁸

    3. Improve High Altitude Performance ⁹

    4. May Enhance Aging ¹⁰ ¹¹

    5. Boost Physical Activity ¹²

    6. Aid In Detoxification ¹³

    7. Help GABA In Brain ¹⁴

    The combination of these benefits has made DHM a powerful supplement choice for alcohol consumption, high altitude journeys, detoxification, and athletic and exercise performance, among its many usages.

    Top Natural DHM-Containing Supplement

    DHM Tablets
    Unlock the full potential of DHM with Zaca's Japanese Raisin infused supplement. This carefully crafted formula is designed with a superior extract of Japanese Raisin rather than isolated DHM — utilizing the seeds, fruit, and peduncle of the powerful plant. With its key ingredient used for centuries, Zaca is made in a fast-acting chewable to help you rehydrate, replenish and recover. Fortified with other liver supporting nutrients such as glutathione. Packaged in portable packets, simply take 2-4 chewables at bedtime or whenever needed. Try Zaca's DHM-containing chewable supplement now and stay at the top of your game every day.



    1. Japanese Raisin: A Rare Herb
    2. Chirality
    3. Chirality of the biomolecules enhanced its stereospecific action of dihydromyricetin enantiomers
    4. Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication
    5. Vine tea (Ampelopsis grossedentata): A review of chemical composition, functional properties, and potential food applications
    6. Semen Hoveniae extract protects against acute alcohol-induced liver injury in mice
    7. Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism
    8. Preclinical Research of Dihydromyricetin for Brain Aging and Neurodegenerative Diseases
    9. Dihydromyricetin improves physical performance under simulated high altitude
    10. Ampelopsin attenuates brain
    11. Social Isolation Induces Neuroinflammation And Microglia Overactivation, While Dihydromyricetin Prevents And Improves Them
    12. Anti-fatigue activity of Hovenia dulcis on a swimming mouse model through the inhibition of stress hormone expression and antioxidation
    13. Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication
    14. Alcohol use disorders and current pharmacological therapies: the role of GABAA receptors
    15. DHM Side Effects
    16. Dihydromyricetin: Uses, Side Effects, Interactions, Dosage, and Science